Pinealon

Pinealon is a synthetic tripeptide, glutamyl-aspartyl-arginine (Glu-Asp-Arg), in the short-regulatory-peptide research family. Investigators study it as a structurally defined research material in neuropeptide and neuroprotection research models, where short peptides of this class are examined for interactions with gene-expression-regulation pathways. The peer-reviewed literature catalogs Pinealon in cell-culture neuroprotection studies and in comparative structure-activity work across short synthetic regulatory peptides. Its molecular identity is fixed by structural confirmation against PubChem CID 10273502, empirical formula C15H26N6O8. The reference material supplied here is intended for laboratory characterization, in-vitro signaling work, and in-cell studies only. For research use only; not for human consumption, medical use, or veterinary application. Researchers should consult primary literature for context-specific experimental conditions.

Pinealon is a short linear tripeptide whose small size and charged side chains (the glutamate and aspartate carboxylates and the arginine guanidinium) are documented in the literature as features enabling short regulatory peptides to reach intracellular and nuclear compartments in research models. The published literature associates peptides of this Glu-Asp-Arg class with modulation of gene-expression and oxidative-stress-response pathways in neuronal-cell research, framed as regulatory rather than receptor-agonist activity. Pharmacokinetic descriptors documented in published animal-model investigations reflect the rapid clearance characteristic of small peptides. All activity descriptors here are framed as documented in published research rather than as effects of the supplied product. Structural confirmation is established by mass spectrometry and HPLC-validated purity on each Certificate of Analysis.

Experimental domains documented in the published literature include neuronal-cell oxidative-stress-response assays, gene-expression-regulation studies, neuroprotection research in cell-culture and animal-model contexts, and comparative structure-activity work across the short-regulatory-tripeptide class. Investigators use Pinealon research material to study how minimal peptide sequences engage intracellular regulatory pathways. Use in laboratory research extends to mechanism-elucidation paradigms where the tripeptide serves as a defined short-regulatory-peptide reference. The reference standard is supplied for these and equivalent in-vitro and animal-model experimental contexts only, with no associated guidance for human, clinical, or veterinary use.

Each lot is characterized by reverse-phase HPLC for chromatographic purity and by mass spectrometry for molecular-ion confirmation against the C15H26N6O8 empirical formula. Purity is reported as an HPLC-area percentage on the Certificate of Analysis distributed with every lot, alongside the molecular-weight match within instrument tolerance. Peptide content where applicable is determined by amino-acid analysis or nitrogen-content assay following the analytical method specified on the COA. Residual solvent and water content are reported categorically when these parameters are part of the lot release specification. The COA records the lot identifier, manufacturing date, and analytical method versions used, providing a traceable provenance chain from synthesis through release. Researchers requiring batch-level analytical detail should reference the COA distributed with the supplied material.

For laboratory storage, the lyophilized reference standard should be held at −20°C in its sealed, light-protected container until ready for analytical use. Allow vials to equilibrate to ambient temperature before opening to avoid moisture condensation on the lyophile. Reconstitution for in-vitro experimental use is typically performed in bacteriostatic water or a researcher-selected buffer compatible with the downstream assay; once reconstituted, store the working solution at 2–8°C and characterize stability in the relevant buffer prior to extended storage. Avoid repeated freeze-thaw cycles of reconstituted material — single-use aliquots are preferred where peptide integrity is assay-critical. These handling parameters reflect general best-practice for lyophilized peptide reference standards and do not constitute preparation guidance for human or veterinary use.